PAR1 High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. Belongs to the G-protein coupled receptor 1 family. Platelets and vascular endothelial cells. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 5q13.3
Cellular Component:  caveola; cell surface; early endosome; extracellular region; Golgi apparatus; late endosome; neuromuscular junction; plasma membrane; platelet dense tubular network; postsynaptic membrane
Molecular Function:  G protein-coupled receptor activity; G-protein alpha-subunit binding; G-protein beta-subunit binding; protein binding; signaling receptor binding; thrombin-activated receptor activity
Biological Process:  activation of cysteine-type endopeptidase activity involved in apoptotic process; anatomical structure morphogenesis; cell-cell junction maintenance; connective tissue replacement involved in inflammatory response wound healing; dendritic cell homeostasis; establishment of synaptic specificity at neuromuscular junction; G protein-coupled receptor signaling pathway; homeostasis of number of cells within a tissue; inflammatory response; negative regulation of cell population proliferation; negative regulation of glomerular filtration; negative regulation of neuron apoptotic process; negative regulation of renin secretion into blood stream; phospholipase C-activating G protein-coupled receptor signaling pathway; platelet activation; platelet dense granule organization; positive regulation of blood coagulation; positive regulation of calcium ion transport; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of collagen biosynthetic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of cytosolic calcium ion concentration; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of DNA-templated transcription; positive regulation of ERK1 and ERK2 cascade; positive regulation of GTPase activity; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of MAPK cascade; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of receptor signaling pathway via JAK-STAT; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of Rho protein signal transduction; positive regulation of smooth muscle contraction; positive regulation of vasoconstriction; protein kinase C-activating G protein-coupled receptor signaling pathway; regulation of blood coagulation; regulation of interleukin-1 beta production; regulation of sensory perception of pain; release of sequestered calcium ion into cytosol; response to lipopolysaccharide; response to wounding; thrombin-activated receptor signaling pathway; trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
Reference #:  P25116 (UniProtKB)
Alt. Names/Synonyms: CF2R; coagulation factor II (thrombin) receptor; Coagulation factor II receptor; coagulation factor II thrombin receptor; F2R; HTR; PAR-1; PAR1; protease-activated receptor 1; Proteinase-activated receptor 1; Thrombin receptor; TR
Gene Symbols: F2R
Molecular weight: 47,441 Da
Basal Isoelectric point: 8.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PAR1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein