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NACA
Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Transcription, coactivator/corepressor |
| Chromosomal Location of Human Ortholog: 10|10 D3 |
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Cellular Component:
cytoplasm; nascent polypeptide-associated complex; nucleus
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Molecular Function:
DNA binding; TBP-class protein binding; transcription coactivator activity
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Biological Process:
cardiac ventricle development; heart trabecula morphogenesis; myoblast migration; negative regulation of striated muscle cell apoptotic process; negative regulation of transcription from RNA polymerase II promoter involved in heart development; positive regulation of cell proliferation involved in heart morphogenesis; positive regulation of skeletal muscle tissue growth; positive regulation of transcription from RNA polymerase II promoter involved in heart development; protein transport; regulation of skeletal muscle fiber development; skeletal muscle tissue regeneration
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Reference #:
P70670
(UniProtKB)
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Alt. Names/Synonyms: AL022831; AL024382; Alpha-NAC, muscle-specific form; alpha-NAC/1.9.2; D12Mgi4; Gm1878; mKIAA0363; Naca; NACAM; nascent polypeptide-associated complex alpha polypeptide; nascent polypeptide-associated complex alpha subunit; nascent polypeptide-associated complex subunit alpha; Nascent polypeptide-associated complex subunit alpha, muscle-specific form; skNAC
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Gene Symbols: Naca
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Molecular weight:
220,499 Da
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Basal Isoelectric point:
9.39
Predict pI for various phosphorylation states
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