NACA Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 10|10 D3
Cellular Component:  cytoplasm; nascent polypeptide-associated complex; nucleus
Molecular Function:  DNA binding; TBP-class protein binding; transcription coactivator activity
Biological Process:  cardiac ventricle development; heart trabecula morphogenesis; myoblast migration; negative regulation of striated muscle cell apoptotic process; negative regulation of transcription from RNA polymerase II promoter involved in heart development; positive regulation of cell proliferation involved in heart morphogenesis; positive regulation of skeletal muscle tissue growth; positive regulation of transcription from RNA polymerase II promoter involved in heart development; protein transport; regulation of skeletal muscle fiber development; skeletal muscle tissue regeneration
Reference #:  P70670 (UniProtKB)
Alt. Names/Synonyms: AL022831; AL024382; Alpha-NAC, muscle-specific form; alpha-NAC/1.9.2; D12Mgi4; Gm1878; mKIAA0363; Naca; NACAM; nascent polypeptide-associated complex alpha polypeptide; nascent polypeptide-associated complex alpha subunit; nascent polypeptide-associated complex subunit alpha; Nascent polypeptide-associated complex subunit alpha, muscle-specific form; skNAC
Gene Symbols: Naca
Molecular weight: 220,499 Da
Basal Isoelectric point: 9.39  Predict pI for various phosphorylation states
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NACA

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein