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SCN2A
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.2/SCN2A subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of rat Ortholog: 3q21 |
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Cellular Component:
axon; axon initial segment; glutamatergic synapse; intercalated disc; membrane; node of Ranvier; paranode region of axon; plasma membrane; presynaptic membrane; sodium channel complex; T-tubule; voltage-gated sodium channel complex
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Molecular Function:
calmodulin binding; growth factor binding; leucine zipper domain binding; protein binding; sodium ion binding; voltage-gated monoatomic ion channel activity; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; voltage-gated sodium channel activity
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Biological Process:
action potential; axon development; cellular response to hypoxia; cerebral cortex development; corpus callosum development; dentate gyrus development; determination of adult lifespan; intrinsic apoptotic signaling pathway in response to osmotic stress; membrane depolarization during action potential; memory; myelination; nerve development; nervous system development; nervous system process; neuron apoptotic process; neuronal action potential; optic nerve development; regulation of monoatomic ion transmembrane transport; regulation of presynaptic membrane potential; sodium ion transmembrane transport; sodium ion transport
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Reference #:
P04775
(UniProtKB)
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Alt. Names/Synonyms: alternative product; NachII; Nav1.2; RII/RIIA; RIIA sodium channel protein; RNSCPIIR; SCN; Scn2a; Scn2a1; Scn2a2; ScpII; Sodium channel protein brain II subunit alpha; Sodium channel protein type 2 subunit alpha; Sodium channel protein type II subunit alpha; sodium channel protein, brain II subunit alpha; sodium channel voltage-gated type II alpha polypeptide; sodium channel, voltage-gated, type 2, alpha 1 polypeptide; sodium channel, voltage-gated, type 2, alpha 1 subunit; sodium channel, voltage-gated, type II, alpha 1; sodium voltage-gated channel alpha subunit 2; Voltage-gated sodium channel subunit alpha Nav1.2
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Gene Symbols: Scn2a
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Molecular weight:
227,874 Da
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Basal Isoelectric point:
5.58
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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