SCN2A Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.2/SCN2A subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3q21
Cellular Component:  axon; axon initial segment; glutamatergic synapse; integral component of presynaptic membrane; intercalated disc; intrinsic component of plasma membrane; membrane; neuron projection; node of Ranvier; paranode region of axon; plasma membrane; sodium channel complex; T-tubule; voltage-gated sodium channel complex
Molecular Function:  leucine zipper domain binding; protein binding; sodium ion binding; voltage-gated ion channel activity; voltage-gated ion channel activity involved in regulation of presynaptic membrane potential; voltage-gated sodium channel activity
Biological Process:  cellular response to hypoxia; intrinsic apoptotic signaling pathway in response to osmotic stress; membrane depolarization during action potential; memory; myelination; nervous system development; neuron apoptotic process; neuronal action potential; regulation of ion transmembrane transport; regulation of presynaptic membrane potential; sodium ion transmembrane transport; sodium ion transport
Reference #:  P04775 (UniProtKB)
Alt. Names/Synonyms: alternative product; NachII; Nav1.2; RII/RIIA; RIIA sodium channel protein; RNSCPIIR; SCN; Scn2a; Scn2a1; Scn2a2; ScpII; Sodium channel protein brain II subunit alpha; Sodium channel protein type 2 subunit alpha; Sodium channel protein type II subunit alpha; sodium channel protein, brain II subunit alpha; sodium channel voltage-gated type II alpha polypeptide; sodium channel, voltage-gated, type 2, alpha 1 polypeptide; sodium channel, voltage-gated, type 2, alpha 1 subunit; sodium channel, voltage-gated, type II, alpha 1; sodium voltage-gated channel alpha subunit 2; Voltage-gated sodium channel subunit alpha Nav1.2
Gene Symbols: Scn2a
Molecular weight: 227,874 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene