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PTPN3
May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor) |
| Chromosomal Location of human Ortholog: 9q31.3 |
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Cellular Component:
cytoplasm; cytoplasmic side of plasma membrane; cytoskeleton; cytosol; plasma membrane
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Molecular Function:
ATPase binding; cytoskeletal protein binding; phosphotyrosine residue binding; protein binding; protein tyrosine phosphatase activity; sodium channel regulator activity
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Biological Process:
liver regeneration; MAPK cascade; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of membrane protein ectodomain proteolysis; negative regulation of mitotic cell cycle; protein dephosphorylation; regulation of membrane depolarization during action potential; regulation of sodium ion transmembrane transporter activity
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Reference #:
P26045
(UniProtKB)
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Alt. Names/Synonyms: cytoskeletal-associated protein tyrosine phosphatase; DKFZp686N0569; protein tyrosin phosphatase H1; protein tyrosine phosphatase non-receptor type 3; protein tyrosine phosphatase, non-receptor type 3; Protein-tyrosine phosphatase H1; PTN3; PTP-H1; PTPH1; PTPN3; tyrosine phosphatase; Tyrosine-protein phosphatase non-receptor type 3
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Gene Symbols: PTPN3
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Molecular weight:
103,990 Da
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Basal Isoelectric point:
6.58
Predict pI for various phosphorylation states
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