PTPN3 May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of human Ortholog: 9q31.3
Cellular Component:  cytoplasm; cytoplasmic side of plasma membrane; cytoskeleton; cytosol; plasma membrane
Molecular Function:  ATPase binding; cytoskeletal protein binding; phosphotyrosine residue binding; protein binding; protein tyrosine phosphatase activity; sodium channel regulator activity
Biological Process:  liver regeneration; MAPK cascade; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of membrane protein ectodomain proteolysis; negative regulation of mitotic cell cycle; protein dephosphorylation; regulation of membrane depolarization during action potential; regulation of sodium ion transmembrane transporter activity
Reference #:  P26045 (UniProtKB)
Alt. Names/Synonyms: cytoskeletal-associated protein tyrosine phosphatase; DKFZp686N0569; protein tyrosin phosphatase H1; protein tyrosine phosphatase non-receptor type 3; protein tyrosine phosphatase, non-receptor type 3; Protein-tyrosine phosphatase H1; PTN3; PTP-H1; PTPH1; PTPN3; tyrosine phosphatase; Tyrosine-protein phosphatase non-receptor type 3
Gene Symbols: PTPN3
Molecular weight: 103,990 Da
Basal Isoelectric point: 6.58  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein