H2A.1 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Belongs to the histone H2A family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of mouse Ortholog: 13|13 A3.1
Cellular Component:  CENP-A containing nucleosome; nucleosome; nucleus
Molecular Function:  DNA binding
Biological Process:  protein localization to CENP-A containing chromatin
Reference #:  C0HKE1 (UniProtKB)
Alt. Names/Synonyms: H2A clustered histone 4; H2a-5; H2a-53; H2A.; H2A.1; H2A1; H2A1B; H2ac4; Hist1h; Hist1h2ab; Hist1h2ac; Hist1h2ad; Hist1h2ae; Hist1h2ag; Hist1h2ai; Hist1h2an; Hist1h2ao; histone 1, H2ab; histone cluster 1, H2ab; Histone H2A type 1; Histone H2A type 1-B; Histone H2A type 1-C; Histone H2A type 1-D; Histone H2A type 1-E; Histone H2A type 1-G; Histone H2A type 1-I; Histone H2A type 1-N; Histone H2A type 1-O; Histone H2A type 1-P; OTTMUSP00000000550
Gene Symbols: H2ac4
Molecular weight: 14,004 Da
Basal Isoelectric point: 11.05  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  BioGPS  |  Pfam  |  RCSB PDB  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein