H2A.1
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Belongs to the histone H2A family. Note: This description may include information from UniProtKB.
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Protein type: DNA-binding |
Chromosomal Location of human Ortholog: 6p22.1 |
Cellular Component:
nucleosome; nucleus
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Molecular Function:
DNA binding; enzyme binding; protein binding; protein heterodimerization activity; structural constituent of chromatin
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Reference #:
P0C0S8
(UniProtKB)
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Alt. Names/Synonyms: FLJ92027; H2A clustered histone 13; H2A histone family, member C; H2A.1; H2A/c; H2A1; H2AC11; H2AC13; H2AC15; H2AC16; H2AC17; H2AFC; H2AFD; H2AFI; H2AFN; H2AFP; HIST1H2AG; HIST1H2AI; HIST1H2AK; HIST1H2AL; HIST1H2AM; histone 1, H2ai; histone cluster 1 H2A family member i; histone cluster 1, H2ai; Histone H2A type 1; Histone H2A/p; Histone H2A/ptl
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Gene Symbols: H2AC11; H2AC13; H2AC15; H2AC16; H2AC17
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Molecular weight:
13,960 Da
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Basal Isoelectric point:
10.9
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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