H2A.1 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Belongs to the histone H2A family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 6p22.1
Cellular Component:  nucleosome; nucleus
Molecular Function:  enzyme binding; protein binding; protein heterodimerization activity
Reference #:  P0C0S8 (UniProtKB)
Alt. Names/Synonyms: FLJ92027; H2A clustered histone 13; H2A histone family, member C; H2A.1; H2A/c; H2A1; H2AC11; H2AC13; H2AC15; H2AC16; H2AC17; H2AFC; H2AFD; H2AFI; H2AFN; H2AFP; HIST1H2AG; HIST1H2AI; HIST1H2AK; HIST1H2AL; HIST1H2AM; histone 1, H2ai; histone cluster 1 H2A family member i; histone cluster 1, H2ai; Histone H2A type 1; Histone H2A/p; Histone H2A/ptl
Gene Symbols: H2AC11; H2AC13; H2AC15; H2AC16; H2AC17
Molecular weight: 13,960 Da
Basal Isoelectric point: 10.9  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

H2A.1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene