CACNA1C Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. (Microbial infection) Acts as a receptor for Influenzavirus. May play a critical role in allowing virus entry when sialylated and expressed on lung tissues. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily. Detected throughout the brain, including hippocampus, cerebellum and amygdala, throughout the heart and vascular system, including ductus arteriosus, in urinary bladder, and in retina and sclera in the eye (PubMed:15454078). Expressed in brain, heart, jejunum, ovary, pancreatic beta-cells and vascular smooth muscle. Overall expression is reduced in atherosclerotic vascular smooth muscle. 26 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: 
Reference #:  P15381 (UniProtKB)
Alt. Names/Synonyms: CAC1C; CACB-receptor; CACH2; CACN2; CACNA1C; CACNL1A1; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; CCAC; CCHL1A1; Smooth muscle calcium channel blocker receptor; Voltage-dependent L-type calcium channel alpha-1C subunit; Voltage-dependent L-type calcium channel subunit alpha-1C; VSCC, L type, alpha 1C
Gene Symbols: CACB
Molecular weight: 242,784 Da
Basal Isoelectric point: 6.59  Predict pI for various phosphorylation states
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CACNA1C

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein