PSMA3 Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. Belongs to the peptidase T1A family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Proteasome complex
Chromosomal Location of Human Ortholog: 6q24
Cellular Component:  cytoplasm; nucleus; proteasome complex; proteasome core complex; proteasome core complex, alpha-subunit complex; synapse
Molecular Function:  endopeptidase activity; threonine-type endopeptidase activity; ubiquitin protein ligase binding
Biological Process:  proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of endopeptidase activity
Reference #:  P18422 (UniProtKB)
Alt. Names/Synonyms: Macropain subunit C8; Multicatalytic endopeptidase complex subunit C8; multicatalytic proteinase subunit K; proteasome (prosome, macropain) subunit, alpha type 3; Proteasome component C8; proteasome subunit alpha type 3-like; Proteasome subunit alpha type-3; proteasome subunit C8; Proteasome subunit K; Psma3; Psma3l
Gene Symbols: Psma3
Molecular weight: 28,419 Da
Basal Isoelectric point: 5.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene