nAChRA7 After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 7/CHRNA7 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1q22
Cellular Component:  acetylcholine-gated channel complex; apical plasma membrane; asymmetric synapse; axolemma; axon; cell junction; cell soma; cytoplasm; dendrite; dendritic shaft; dendritic spine; external side of plasma membrane; growth cone; integral component of membrane; integral component of plasma membrane; membrane; membrane raft; neuron projection; plasma membrane; postsynaptic density; postsynaptic membrane; presynaptic membrane; synapse
Molecular Function:  acetylcholine binding; acetylcholine receptor activity; acetylcholine-gated cation channel activity; adenylate cyclase binding; amyloid-beta binding; ATPase binding; chloride channel regulator activity; drug binding; extracellular ligand-gated ion channel activity; ion channel activity; protein binding; protein homodimerization activity; protein kinase binding; toxin binding; transmembrane receptor activity
Biological Process:  activation of MAPK activity; associative learning; B cell activation; behavioral response to ethanol; behavioral response to nicotine; calcium ion transport; cellular calcium ion homeostasis; cognition; dendrite arborization; dopamine biosynthetic process; endocytosis; excitatory postsynaptic potential; generation of action potential; generation of ovulation cycle rhythm; ion transport; learning and/or memory; memory; modulation of excitatory postsynaptic potential; negative regulation of ERK1 and ERK2 cascade; negative regulation of inflammatory response; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 production; negative regulation of protein phosphorylation; negative regulation of tumor necrosis factor production; neurological system process; ovulation cycle; positive regulation of amyloid-beta formation; positive regulation of angiogenesis; positive regulation of cell proliferation; positive regulation of CoA-transferase activity; positive regulation of ERK1 and ERK2 cascade; positive regulation of excitatory postsynaptic potential; positive regulation of heart rate in baroreceptor response to decreased systemic arterial blood pressure; positive regulation of long-term synaptic potentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein metabolic process; positive regulation of protein phosphorylation; regulation of amyloid fibril formation; regulation of inflammatory response; regulation of membrane potential; regulation of neuron death; regulation of norepinephrine secretion; regulation of synaptic transmission; regulation of synaptic transmission, dopaminergic; response to acetylcholine; response to amyloid-beta; response to cold; response to ethanol; response to food; response to hypoxia; response to nicotine; sensory processing; signal transduction; sperm motility; synapse organization; synaptic transmission; synaptic transmission, cholinergic; T cell activation
Reference #:  Q05941 (UniProtKB)
Alt. Names/Synonyms: ACHA7; Acra7; BTX; bungarotoxin alpha; C holinergic receptor nicotinic alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha); C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha); cholinergic receptor, nicotinic, alpha 7; cholinergic receptor, nicotinic, alpha polypeptide 7; Chrna7; nAChRa7; NARAD; Neuronal acetylcholine receptor subunit alpha-7; neuronal nicotinic acetycholine receptor alpha 7; nicotinic receptor alpha 7 subunit
Gene Symbols: Chrna7
Molecular weight: 56,503 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene