MYH9 Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. In the kidney, expressed in the glomeruli. Also expressed in leukocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of human Ortholog: 22q12.3
Cellular Component:  actin cytoskeleton; actomyosin; actomyosin contractile ring; adherens junction; brush border; cell leading edge; cleavage furrow; cortical granule; cytoplasm; cytoplasmic side of plasma membrane; cytosol; focal adhesion; immunological synapse; myosin filament; myosin II complex; myosin II filament; neuromuscular junction; nuclear body; nucleus; plasma membrane; protein-containing complex; ruffle; spindle; stress fiber; uropod
Molecular Function:  actin binding; actin filament binding; ADP binding; ATP binding; calmodulin binding; cytoskeletal motor activity; identical protein binding; integrin binding; microfilament motor activity; protein binding; protein domain specific binding; protein homodimerization activity; protein-membrane adaptor activity
Biological Process:  actin cytoskeleton organization; actin filament-based movement; actomyosin structure organization; angiogenesis; blood vessel endothelial cell migration; cortical granule exocytosis; cytokinetic process; establishment of meiotic spindle localization; establishment of T cell polarity; in utero embryonic development; integrin-mediated signaling pathway; leukocyte migration; lysosome localization; meiotic spindle organization; membrane protein ectodomain proteolysis; monocyte differentiation; myoblast fusion; negative regulation of actin filament severing; phagocytosis, engulfment; plasma membrane repair; platelet formation; positive regulation of protein processing in phagocytic vesicle; protein transport; regulated exocytosis; regulation of cell shape; regulation of plasma membrane repair; uropod organization
Disease: Deafness, Autosomal Dominant 17; May-hegglin Anomaly
Reference #:  P35579 (UniProtKB)
Alt. Names/Synonyms: BDPLT6; Cellular myosin heavy chain, type A; DFNA17; EPSTS; FTNS; MATINS; MGC104539; MHA; MYH9; MYH9 variant protein; Myosin heavy chain 9; Myosin heavy chain, non-muscle IIa; myosin, heavy chain 9, non-muscle; Myosin-9; NMHC-II-A; NMMHC II-a; NMMHC-A; NMMHC-IIA; NMMHCA; non-muscle myosin heavy chain 9; Non-muscle myosin heavy chain A; Non-muscle myosin heavy chain IIa; non-muscle myosin heavy polypeptide 9; nonmuscle myosin heavy chain II-A
Gene Symbols: MYH9
Molecular weight: 226,532 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein