MYH9 Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Interacts with PDLIM2. Interacts with SLC6A4. Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with RASIP1. Interacts with DDR1. Interacts with SVIL and HTRA3. In the kidney, expressed in the glomeruli. Also expressed in leukocytes. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 22q12.3
Cellular Component:  actin cytoskeleton; actomyosin; actomyosin contractile ring; brush border; cell leading edge; cell-cell adherens junction; cleavage furrow; cytoplasm; cytosol; myosin II complex; myosin II filament; neuromuscular junction; nucleus; plasma membrane; protein-containing complex; ruffle; spindle; stress fiber; uropod
Molecular Function:  actin binding; actin filament binding; actin-dependent ATPase activity; ADP binding; ATP binding; ATPase activity; calmodulin binding; integrin binding; microfilament motor activity; motor activity; protein binding; protein domain specific binding; protein homodimerization activity; protein membrane anchor
Biological Process:  actin cytoskeleton reorganization; actin filament-based movement; actomyosin structure organization; angiogenesis; blood vessel endothelial cell migration; cytokinetic process; establishment of meiotic spindle localization; establishment of T cell polarity; in utero embryonic development; integrin-mediated signaling pathway; leukocyte migration; lysosome localization; meiotic spindle organization; membrane protein ectodomain proteolysis; monocyte differentiation; myoblast fusion; negative regulation of actin filament severing; phagocytosis, engulfment; plasma membrane repair; platelet formation; positive regulation of protein processing in phagocytic vesicle; protein transport; regulated exocytosis; regulation of cell shape; regulation of plasma membrane repair; uropod organization
Disease: Deafness, Autosomal Dominant 17; May-hegglin Anomaly
Reference #:  P35579 (UniProtKB)
Alt. Names/Synonyms: Cellular myosin heavy chain, type A; DFNA17; EPSTS; FTNS; MGC104539; MHA; MYH9; MYH9 variant protein; Myosin heavy chain 9; Myosin heavy chain, non-muscle IIa; myosin, heavy chain 9, non-muscle; Myosin-9; NMHC-II-A; NMMHC II-a; NMMHC-A; NMMHC-IIA; NMMHCA; Non-muscle myosin heavy chain A; Non-muscle myosin heavy chain IIa; non-muscle myosin heavy polypeptide 9; nonmuscle myosin heavy chain II-A
Gene Symbols: MYH9
Molecular weight: 226,532 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB