NKX2-1 Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1. Belongs to the NK-2 homeobox family. Thyroid and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; DNA-binding; Transcription factor
Chromosomal Location of rat Ortholog: 6q23
Cellular Component:  nucleoplasm; nucleus; transcription regulator complex
Molecular Function:  core promoter sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; identical protein binding; intronic transcription regulatory region sequence-specific DNA binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; TBP-class protein binding; transcription cis-regulatory region binding; transcription coactivator activity; transcription coregulator binding
Biological Process:  anatomical structure formation involved in morphogenesis; animal organ morphogenesis; axon guidance; brain development; cell differentiation; cellular response to leptin stimulus; cerebral cortex cell migration; cerebral cortex GABAergic interneuron differentiation; cerebral cortex neuron differentiation; circadian rhythm; club cell differentiation; development of primary female sexual characteristics; developmental induction; embryonic lung development; endoderm development; epithelial tube branching involved in lung morphogenesis; feeding behavior; forebrain development; forebrain dorsal/ventral pattern formation; forebrain neuron differentiation; forebrain neuron fate commitment; GABAergic neuron differentiation; gene expression; globus pallidus development; hippocampus development; hypothalamus development; interneuron migration; Leydig cell differentiation; locomotory behavior; lung development; lung saccule development; negative regulation of cell migration; negative regulation of DNA-templated transcription; negative regulation of epithelial to mesenchymal transition; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; neuron fate commitment; neuron migration; oligodendrocyte differentiation; pattern specification process; phospholipid metabolic process; pituitary gland development; positive regulation of circadian rhythm; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of transcription by RNA polymerase II; regulation of blood volume by renin-angiotensin; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to ethanol; response to hormone; response to lipopolysaccharide; telencephalon cell migration; telencephalon development; thyroid gland development; type II pneumocyte differentiation
Reference #:  P23441 (UniProtKB)
Alt. Names/Synonyms: Homeobox protein Nkx-2.1; NK2 homeobox 1; Nkx-2.1; Nkx2-1; NKX21; Thyroid nuclear factor 1; Thyroid transcription factor 1; thyroid transcription factor 1 TTF-1 NK-2; Titf1; TTF-1; Ttf1
Gene Symbols: Nkx2-1
Molecular weight: 38,554 Da
Basal Isoelectric point: 9.72  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene