ADORA2A Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 10|10 C1
Cellular Component:  asymmetric synapse; axolemma; axon; dendrite; endomembrane system; glutamatergic synapse; integral component of membrane; integral component of plasma membrane; integral component of postsynaptic membrane; integral component of presynaptic membrane; membrane; neuronal cell body; plasma membrane; postsynaptic density; postsynaptic membrane; presynaptic active zone; presynaptic membrane
Molecular Function:  alpha-actinin binding; enzyme binding; G protein-coupled adenosine receptor activity; G protein-coupled receptor activity; identical protein binding; protein heterodimerization activity; type 5 metabotropic glutamate receptor binding
Biological Process:  adenosine receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; astrocyte activation; eating behavior; excitatory postsynaptic potential; G protein-coupled receptor signaling pathway; inhibitory postsynaptic potential; locomotory behavior; membrane depolarization; negative regulation of alpha-beta T cell activation; negative regulation of cell proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of inflammatory response; negative regulation of locomotion; negative regulation of neuron apoptotic process; negative regulation of protein kinase activity; negative regulation of vascular permeability; neuron projection morphogenesis; positive regulation of acetylcholine secretion, neurotransmission; positive regulation of apoptotic signaling pathway; positive regulation of circadian sleep/wake cycle, sleep; positive regulation of glutamate secretion; positive regulation of long-term synaptic potentiation; positive regulation of protein secretion; positive regulation of renal sodium excretion; positive regulation of synaptic transmission, GABAergic; positive regulation of synaptic transmission, glutamatergic; positive regulation of urine volume; prepulse inhibition; protein kinase C-activating G protein-coupled receptor signaling pathway; regulation of calcium ion transport; regulation of mitochondrial membrane potential; regulation of norepinephrine secretion; regulation of synaptic vesicle exocytosis; regulation of transcription, DNA-templated; response to alkaloid; response to amphetamine; response to caffeine; signal transduction; synaptic transmission, cholinergic; synaptic transmission, dopaminergic; synaptic transmission, glutamatergic; vasodilation
Reference #:  Q60613 (UniProtKB)
Alt. Names/Synonyms: A2a, Rs; A2AAR; A2aR; AA2AR; adenosine A2a receptor; Adenosine receptor A2a; Adora2a; MGC118414
Gene Symbols: Adora2a
Molecular weight: 44,971 Da
Basal Isoelectric point: 8.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene