Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Cellular Component: asymmetric synapse; axolemma; axon; dendrite; endomembrane system; glutamatergic synapse; integral component of membrane; integral component of plasma membrane; integral component of postsynaptic membrane; integral component of presynaptic membrane; membrane; neuronal cell body; plasma membrane; postsynaptic density; postsynaptic membrane; presynaptic active zone; presynaptic membrane
Molecular Function: alpha-actinin binding; enzyme binding; G protein-coupled adenosine receptor activity; G protein-coupled receptor activity; identical protein binding; protein heterodimerization activity; type 5 metabotropic glutamate receptor binding
Biological Process: adenosine receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; astrocyte activation; eating behavior; excitatory postsynaptic potential; G protein-coupled receptor signaling pathway; inhibitory postsynaptic potential; locomotory behavior; membrane depolarization; negative regulation of alpha-beta T cell activation; negative regulation of cell proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of inflammatory response; negative regulation of locomotion; negative regulation of neuron apoptotic process; negative regulation of protein kinase activity; negative regulation of vascular permeability; neuron projection morphogenesis; positive regulation of acetylcholine secretion, neurotransmission; positive regulation of apoptotic signaling pathway; positive regulation of circadian sleep/wake cycle, sleep; positive regulation of glutamate secretion; positive regulation of long-term synaptic potentiation; positive regulation of protein secretion; positive regulation of renal sodium excretion; positive regulation of synaptic transmission, GABAergic; positive regulation of synaptic transmission, glutamatergic; positive regulation of urine volume; prepulse inhibition; protein kinase C-activating G protein-coupled receptor signaling pathway; regulation of calcium ion transport; regulation of mitochondrial membrane potential; regulation of norepinephrine secretion; regulation of synaptic vesicle exocytosis; regulation of transcription, DNA-templated; response to alkaloid; response to amphetamine; response to caffeine; signal transduction; synaptic transmission, cholinergic; synaptic transmission, dopaminergic; synaptic transmission, glutamatergic; vasodilation