PDE1A Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP. Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. 9 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase
Cellular Component: 
Molecular Function:  calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; calmodulin binding; calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; metal ion binding; protein binding
Biological Process:  signal transduction
Reference #:  P14100 (UniProtKB)
Alt. Names/Synonyms: 61 kDa Cam-PDE; Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; Cam-PDE 1A; CN1A; PDE1A
Gene Symbols: PDE1A
Molecular weight: 60,843 Da
Basal Isoelectric point: 5.63  Predict pI for various phosphorylation states
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PDE1A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein