CYP3A5 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Belongs to the cytochrome P450 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - retinol; EC; Lipid Metabolism - linoleic acid; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of Human Ortholog: 12p11
Cellular Component:  endoplasmic reticulum membrane; integral component of membrane; intracellular membrane-bounded organelle
Molecular Function:  aromatase activity; demethylase activity; heme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; testosterone 6-beta-hydroxylase activity
Biological Process:  aging; drug metabolic process; oxidation-reduction process; oxidative demethylation; response to cadmium ion; response to drug; response to glucocorticoid; response to metal ion; response to nutrient
Reference #:  P04800 (UniProtKB)
Alt. Names/Synonyms: cDEX; CP3A1; CYP; Cyp3a-1; Cyp3a1; CYP3A23; Cyp3a23/3a1; Cyp3a3; CYPIIIA1; cytochrome P-450PCN (PNCN inducible); Cytochrome P450 3A1; cytochrome P450, family 3, subfamily a, polypeptide 1; cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1; cytochrome P450, subfamily 3A, polypeptide 3; Cytochrome P450, subfamily IIIA, polypeptide 3; Cytochrome P450-PCN1; cytochrome P450/6 beta B; MGC108757; P450 IIIA; P450-PCN1; RL33
Gene Symbols: Cyp3a1
Molecular weight: 57,918 Da
Basal Isoelectric point: 8.81  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene