TGM1 Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation. Belongs to the transglutaminase superfamily. Transglutaminase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.3.2.13; Transferase
Chromosomal Location of Human Ortholog: 14|14 C3
Cellular Component:  cell-cell adherens junction; intrinsic component of membrane; membrane
Molecular Function:  metal ion binding; protein-glutamine gamma-glutamyltransferase activity; transferase activity; transferase activity, transferring acyl groups
Biological Process:  animal organ morphogenesis; keratinization; keratinocyte differentiation; peptide cross-linking; positive regulation of cell cycle; positive regulation of keratinocyte proliferation; protein metabolic process
Reference #:  Q9JLF6 (UniProtKB)
Alt. Names/Synonyms: 2310004J08Rik; Epidermal TGase; K polypeptide; Protein-glutamine gamma-glutamyltransferase K; protein-glutamine-gamma-glutamyltransferase; TG K; TG(K); TGas; TGase 1; TGase K; TGase-1; Tgase1; TGK; Tgm1; transglutaminase 1, K polypeptide; Transglutaminase K; transglutaminase type 1; Transglutaminase-1
Gene Symbols: Tgm1
Molecular weight: 89,826 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
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TGM1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene