RGS18 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha. Expressed in peripheral leukocytes, bone marrow, platelet, spleen and fetal liver. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, RGS
Chromosomal Location of human Ortholog: 1q31.2
Cellular Component:  cytoplasm; plasma membrane
Molecular Function:  GTPase activator activity; GTPase activity; protein binding
Biological Process:  G protein-coupled receptor signaling pathway; negative regulation of signal transduction; positive regulation of GTPase activity; regulation of G protein-coupled receptor signaling pathway
Reference #:  Q9NS28 (UniProtKB)
Alt. Names/Synonyms: regulator of G protein signaling 18; Regulator of G-protein signaling 18; regulator of G-protein signalling 13; regulator of G-protein signalling 18; RGS13; RGS18
Gene Symbols: RGS18
Molecular weight: 27,582 Da
Basal Isoelectric point: 7.73  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene