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TMEM5
UDP-xylosyltransferase involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Acts as a UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase, which catalyzes the transfer of UDP-D-xylose to ribitol 5-phosphate (Rbo5P) to form the Xylbeta1-4Rbo5P linkage on O-mannosyl glycan. Belongs to the RXYLT1 family. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.4.2.-; Membrane protein, integral; Transferase |
| Chromosomal Location of human Ortholog: 12q14.2 |
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Cellular Component:
Golgi apparatus; Golgi membrane; nucleoplasm; plasma membrane
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Molecular Function:
protein binding; ribitol beta-1,4-xylosyltransferase activity
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Biological Process:
protein O-linked mannosylation
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Disease: Muscular Dystrophy-dystroglycanopathy (congenital With Brain And Eye Anomalies), Type A, 10
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Reference #:
Q9Y2B1
(UniProtKB)
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Alt. Names/Synonyms: HP10481; MDDGA10; putative type II membrane protein; ribitol xylosyltransferase 1; Ribitol-5-phosphate xylosyltransferase 1; RXLT1; RXYLT1; TMEM5; Transmembrane protein 5; type II membrane protein; UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase
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Gene Symbols: RXYLT1
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Molecular weight:
51,146 Da
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Basal Isoelectric point:
8.57
Predict pI for various phosphorylation states
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