dUTPase This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. Belongs to the dUTPase family. Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression correlates with the onset of DNA replication (at protein level). Isoform 2 degradation coincides with the cessation of nuclear DNA replication (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA replication; EC; Hydrolase; Mitochondrial; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine
Cellular Component:  cytoplasm; nucleoplasm; nucleus
Molecular Function:  dUTP diphosphatase activity; identical protein binding; magnesium ion binding; peroxisome proliferator activated receptor binding; pyrimidine deoxyribonucleotide binding; signaling receptor inhibitor activity
Biological Process:  dTMP biosynthetic process; dUMP biosynthetic process; dUTP catabolic process; liver development; regulation of protein-containing complex assembly; response to organic cyclic compound
Reference #:  P70583 (UniProtKB)
Alt. Names/Synonyms: Deoxyuridine 5'-triphosphate nucleotidohydrolase; deoxyuridine triphosphatase pseudogene; Dut; Dut-ps; Dutp; dUTP pyrophosphatase; dUTPase; PIP4; PPAR-interacting protein 4
Gene Symbols: Dut
Molecular weight: 22,003 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein