CFD Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Belongs to the peptidase S1 family. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 19p13.3
Cellular Component:  extracellular region; ficolin-1-rich granule lumen; platelet alpha granule lumen; secretory granule lumen
Molecular Function:  serine-type endopeptidase activity; serine-type peptidase activity
Biological Process:  complement activation; complement activation, alternative pathway; neutrophil degranulation; platelet degranulation; proteolysis
Disease: Complement Factor D Deficiency
Reference #:  P00746 (UniProtKB)
Alt. Names/Synonyms: Adipsin; ADN; C3 convertase activator; CFAD; CFD; Complement factor D; complement factor D (adipsin); complement factor D preproprotein; D component of complement (adipsin); DF; PFD; Properdin factor D
Gene Symbols: CFD
Molecular weight: 27,033 Da
Basal Isoelectric point: 7.65  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB