CFD Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Belongs to the peptidase S1 family. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of mouse Ortholog: 10 C1|10 39.72 cM
Cellular Component:  extracellular region; extracellular space
Molecular Function:  endopeptidase activity; hydrolase activity; peptidase activity; serine-type endopeptidase activity; serine-type peptidase activity
Biological Process:  complement activation, alternative pathway; immune system process; innate immune response; Notch signaling pathway; proteolysis; response to bacterium
Reference #:  P03953 (UniProtKB)
Alt. Names/Synonyms: 28 kDa adipocyte protein; Adipsin; Adn; C3 convertase activator; CFAD; Cfd; Complement factor D; complement factor D (adipsin); D component (adipsin) of complement; Df; Properdin factor D
Gene Symbols: Cfd
Molecular weight: 28,057 Da
Basal Isoelectric point: 6.18  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene