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CTNNBIP1
Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. Belongs to the CTNNBIP1 family. Note: This description may include information from UniProtKB.
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| Protein type: Cell development/differentiation; Inhibitor |
| Chromosomal Location of human Ortholog: 1p36.22 |
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Cellular Component:
beta-catenin destruction complex; beta-catenin-ICAT complex; cytoplasm; cytosol; nucleoplasm; nucleus
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Molecular Function:
armadillo repeat domain binding; beta-catenin binding; protein binding
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Biological Process:
anterior/posterior pattern specification; branching involved in ureteric bud morphogenesis; negative regulation of canonical Wnt signaling pathway; negative regulation of DNA binding; negative regulation of DNA-binding transcription factor activity; negative regulation of mesenchymal cell proliferation; negative regulation of protein binding; negative regulation of protein-containing complex assembly; negative regulation of smooth muscle cell proliferation; negative regulation of transcription initiation by RNA polymerase II; negative regulation of Wnt signaling pathway; positive regulation of monocyte differentiation; positive regulation of osteoblast differentiation; regulation of vascular permeability involved in acute inflammatory response; Wnt signaling pathway
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Reference #:
Q9NSA3
(UniProtKB)
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Alt. Names/Synonyms: Beta-catenin-interacting protein 1; beta-catenin-interacting protein ICAT; catenin beta interacting protein 1; catenin, beta interacting protein 1; catenin, beta-interacting protein 1; CNBP1; CTNNBIP1; ICAT; Inhibitor of beta-catenin and Tcf-4; MGC15093
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Gene Symbols: CTNNBIP1
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Molecular weight:
9,170 Da
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Basal Isoelectric point:
5.33
Predict pI for various phosphorylation states
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CST Pathways:
Wnt/ß-Catenin Signaling
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