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SPRED3
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Expression is restricted to liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Chromosomal Location of human Ortholog: 19q13.2 |
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Cellular Component:
plasma membrane
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Molecular Function:
protein kinase binding
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Biological Process:
negative regulation of epithelial to mesenchymal transition; negative regulation of ERK1 and ERK2 cascade; negative regulation of lens fiber cell differentiation; negative regulation of MAPK cascade; negative regulation of transforming growth factor beta receptor signaling pathway
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Reference #:
Q2MJR0
(UniProtKB)
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Alt. Names/Synonyms: Eve-3; SPRE3; Spred-3; SPRED3; sprouty related EVH1 domain containing 3; sprouty-related, EVH1 domain containing 3; Sprouty-related, EVH1 domain-containing protein 3
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Gene Symbols: SPRED3
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Molecular weight:
42,670 Da
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Basal Isoelectric point:
8.67
Predict pI for various phosphorylation states
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CST Pathways:
Growth And Differentiation Control by MAPKs
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