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dUTPase iso2
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. Belongs to the dUTPase family. Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression correlates with the onset of DNA replication (at protein level). Isoform 2 degradation coincides with the cessation of nuclear DNA replication (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA replication; EC 3.6.1.23; Hydrolase; Mitochondrial; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine |
| Chromosomal Location of human Ortholog: 15q21.1 |
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Cellular Component:
mitochondrion; nucleoplasm; nucleus
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Molecular Function:
dUTP diphosphatase activity; identical protein binding; magnesium ion binding; peroxisome proliferator activated receptor binding; protein binding; pyrimidine deoxyribonucleotide binding; signaling receptor inhibitor activity
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Biological Process:
DNA replication; dTMP biosynthetic process; dUMP biosynthetic process; dUTP catabolic process; liver development; nucleobase-containing compound metabolic process; regulation of protein-containing complex assembly; response to organic cyclic compound
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Disease: Bone Marrow Failure And Diabetes Mellitus Syndrome
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Reference #:
P33316-2
(UniProtKB)
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Alt. Names/Synonyms: Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial; deoxyuridine triphosphatase; DUT; dUTP diphosphatase; dUTP nucleotidohydrolase; dUTP pyrophosphatase; dUTPase; dUTPase iso2; FLJ20622
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Gene Symbols: DUT
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Molecular weight:
17,748 Da
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Basal Isoelectric point:
6.15
Predict pI for various phosphorylation states
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