dUTPase iso2 This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. Belongs to the dUTPase family. Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression correlates with the onset of DNA replication (at protein level). Isoform 2 degradation coincides with the cessation of nuclear DNA replication (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA replication; EC 3.6.1.23; Hydrolase; Mitochondrial; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine
Chromosomal Location of Human Ortholog: 15q21.1
Cellular Component:  mitochondrion; nucleoplasm; nucleus
Molecular Function:  protein binding
Biological Process:  DNA replication; dUMP biosynthetic process; nucleobase-containing compound metabolic process; nucleobase-containing small molecule interconversion
Reference #:  P33316-2 (UniProtKB)
Alt. Names/Synonyms: Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial; deoxyuridine triphosphatase; DUT; dUTP nucleotidohydrolase; dUTP pyrophosphatase; dUTPase; FLJ20622
Gene Symbols: DUT
Molecular weight: 17,748 Da
Basal Isoelectric point: 6.15  Predict pI for various phosphorylation states
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dUTPase iso2

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein