Ugt1a6a UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1. Belongs to the UDP-glycosyltransferase family. Expressed in skin. Isoforms 1 and 3 are expressed in kidney and liver. Isoform 1 but not isoform 2 is expressed in colon, esophagus and small intestine. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Cofactor and Vitamin Metabolism - retinol; EC 2.4.1.17; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Mitochondrial; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of Human Ortholog: 1|1 D
Cellular Component:  endoplasmic reticulum; intracellular membrane-bounded organelle; protein-containing complex
Molecular Function:  enzyme binding; glucuronosyltransferase activity; protein heterodimerization activity; protein homodimerization activity; protein-containing complex binding; UDP-glycosyltransferase activity
Biological Process:  flavonoid glucuronidation; glucuronate metabolic process; xenobiotic glucuronidation
Reference #:  Q64435 (UniProtKB)
Alt. Names/Synonyms: OTTMUSP00000022770; OTTMUSP00000022771; Phenol UDP-glucuronosyltransferase; UD16; UDP glucuronosyltransferase 1 family, polypeptide A6A; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1-6; UDP-glucuronosyltransferase 1A6; UDPGT; UDPGT 1-6; UGP1A1; Ugt1; UGT1*6; UGT1-06; UGT1.6; Ugt1a; UGT1A6; Ugt1a6a; Ugt1a7
Gene Symbols: Ugt1a6a
Molecular weight: 60,439 Da
Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Ugt1a6a

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene