SLAP2 Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. Predominantly expressed in immune system, with highest levels in peripheral blood leukocytes. Expressed in spleen, thymus and lymph nodes. Expressed in T-cells as well as in monocytes, and at low level in B-cells. Also detected in placenta, prostate, skin, retina and colon. 4 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Vesicle
Chromosomal Location of human Ortholog: 20q11.23
Cellular Component:  cytoplasm; cytosol; endosome membrane; Golgi apparatus; intracellular membrane-bounded organelle; late endosome; nucleoplasm; phosphatidylinositol 3-kinase complex; plasma membrane
Molecular Function:  1-phosphatidylinositol-3-kinase regulator activity; protein binding; protein N-terminus binding; signaling adaptor activity
Biological Process:  antigen receptor-mediated signaling pathway; B cell mediated immunity; negative regulation of calcium-mediated signaling; negative regulation of T cell receptor signaling pathway; negative regulation of transcription by RNA polymerase II; phosphatidylinositol phosphate biosynthetic process; regulation of immune response; regulation of phosphatidylinositol 3-kinase activity; T cell activation
Reference #:  Q9H6Q3 (UniProtKB)
Alt. Names/Synonyms: C20orf156; FLJ21992; MARS; MGC49845; Modulator of antigen receptor signaling; SLA2; SLAP-2; SLAP2; Src like adaptor 2; Src-like adapter protein 2; Src-like adapter protein-2; Src-like-adapter 2; Src-like-adaptor 2
Gene Symbols: SLA2
Molecular weight: 28,585 Da
Basal Isoelectric point: 5.23  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene