TUBB3 Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord. Belongs to the tubulin family. Expression is primarily restricted to central and peripheral nervous system. Greatly increased expression in most cancerous tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8|8 E1
Cellular Component:  axon; cell periphery; cytoplasm; cytoskeleton; dendrite; filopodium; growth cone; lamellipodium; microtubule; microtubule cytoskeleton; neuronal cell body
Molecular Function:  GTP binding; GTPase activity; netrin receptor binding; nucleotide binding; peptide binding; protein binding; structural constituent of cytoskeleton
Biological Process:  axon guidance; dorsal root ganglion development; microtubule cytoskeleton organization; microtubule-based process; mitotic cell cycle; netrin-activated signaling pathway; neuron differentiation
Reference #:  Q9ERD7 (UniProtKB)
Alt. Names/Synonyms: 3200002H15Rik; betaIII-tubulin; M(beta)3; M(beta)6; TBB3; Tubb3; Tubulin beta-3 chain; tubulin, beta 3
Gene Symbols: Tubb3
Molecular weight: 50,419 Da
Basal Isoelectric point: 4.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene