TRIM72 Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles. Belongs to the TRIM/RBCC family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component:  cytoplasmic vesicle membrane; sarcolemma
Molecular Function:  phosphatidylserine binding; protein binding; ubiquitin conjugating enzyme binding; ubiquitin protein ligase activity; zinc ion binding
Biological Process:  exocytosis; muscle contraction; muscle organ development; muscle system process; negative regulation of insulin receptor signaling pathway; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of myotube differentiation; plasma membrane repair; proteasome-mediated ubiquitin-dependent protein catabolic process; protein homooligomerization; protein ubiquitination
Reference #:  Q6ZMU5 (UniProtKB)
Alt. Names/Synonyms: MG53; Mitsugumin-53; TRI72; TRIM72; tripartite motif containing 72; tripartite motif containing 72, E3 ubiquitin protein ligase; tripartite motif-containing 72; Tripartite motif-containing protein 72
Gene Symbols: TRIM72
Molecular weight: 52,731 Da
Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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