TCEA3 Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. Belongs to the TFS-II family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 1p36.12
Cellular Component:  nucleus
Molecular Function:  DNA binding; zinc ion binding
Biological Process:  regulation of transcription, DNA-templated; transcription, DNA-templated
Reference #:  O75764 (UniProtKB)
Alt. Names/Synonyms: rhabdomyosarcoma antigen MU-RMS-40.22; TCEA3; TFIIS; TFIIS.H; TFIISH; transcription elongation factor A (SII), 3; Transcription elongation factor A protein 3; transcription elongation factor A3; Transcription elongation factor S-II protein 3; Transcription elongation factor TFIIS.h
Gene Symbols: TCEA3
Molecular weight: 38,972 Da
Basal Isoelectric point: 9.32  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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