SGCA Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Belongs to the sarcoglycan alpha/epsilon family. Most strongly expressed in skeletal muscle. Also expressed in cardiac muscle and, at much lower levels, in lung. In the fetus, most abundant in cardiac muscle and, at lower levels, in lung. Also detected in liver and kidney. Not expressed in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q21.33
Cellular Component:  cell-cell junction; cytoplasm; cytoskeleton; dystrophin-associated glycoprotein complex; integral component of membrane; membrane raft; sarcolemma
Molecular Function:  calcium ion binding; protein binding
Biological Process:  muscle contraction; muscle organ development; response to denervation involved in regulation of muscle adaptation; skeletal muscle tissue regeneration
Disease: Muscular Dystrophy, Limb-girdle, Type 2d
Reference #:  Q16586 (UniProtKB)
Alt. Names/Synonyms: 50 kDa dystrophin-associated glycoprotein; 50-DAG; 50DAG; 50kD DAG; A2; Adhalin; ADL; Alpha-sarcoglycan; Alpha-SG; DAG2; DMDA2; Dystroglycan-2; LGMD2D; LGMDR3; limb girdle muscular dystrophy 2D; sarcoglycan alpha; sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein); SCARMD1; SGCA
Gene Symbols: SGCA
Molecular weight: 42,875 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene