Desmoplakin Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. Homodimer. Interacts with COL17A1 (via cytoplasmic region). Associates (via C-terminal) with KRT5-KRT14 (via rod region), KRT8-KRT18 and VIM intermediate filaments. Interacts with DSC2. Isoform DPI is apparently an obligate constituent of all desmosomes. Isoform DPII resides predominantly in tissues and cells of stratified origin. Belongs to the plakin or cytolinker family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6p24.3
Cellular Component:  basolateral plasma membrane; cornified envelope; desmosome; fascia adherens; ficolin-1-rich granule membrane; intercalated disc; plasma membrane
Molecular Function:  cell adhesion molecule binding; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication; protein binding; protein kinase C binding; scaffold protein binding; structural constituent of cytoskeleton
Biological Process:  adherens junction organization; bundle of His cell-Purkinje myocyte adhesion involved in cell communication; cornification; desmosome organization; epidermis development; intermediate filament organization; keratinization; keratinocyte differentiation; neutrophil degranulation; peptide cross-linking; protein localization to adherens junction; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential; ventricular compact myocardium morphogenesis
Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 8; Cardiomyopathy, Dilated, With Woolly Hair And Keratoderma; Cardiomyopathy, Dilated, With Woolly Hair, Keratoderma, And Tooth Agenesis; Epidermolysis Bullosa, Lethal Acantholytic; Keratosis Palmoplantaris Striata Ii; Skin Fragility-woolly Hair Syndrome
Reference #:  P15924 (UniProtKB)
Alt. Names/Synonyms: 250/210 kDa paraneoplastic pemphigus antigen; Desmoplakin; desmoplakin I; desmoplakin II; DESP; DP; DPI; DPII; DSP
Gene Symbols: DSP
Molecular weight: 331,774 Da
Basal Isoelectric point: 6.44  Predict pI for various phosphorylation states
Select Structure to View Below

Desmoplakin

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein