MCHR1 Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. Belongs to the G-protein coupled receptor 1 family. Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 22q13.2
Cellular Component:  ciliary membrane; cilium; neuron projection; non-motile cilium; plasma membrane
Molecular Function:  G protein-coupled receptor activity; hormone binding; melanin-concentrating hormone receptor activity; neuropeptide binding; neuropeptide receptor activity; peptide binding; protein C-terminus binding; signaling receptor binding
Biological Process:  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; feeding behavior; G protein-coupled receptor signaling pathway; generation of precursor metabolites and energy; neuropeptide signaling pathway; positive regulation of calcium ion transport; positive regulation of cytosolic calcium ion concentration
Reference #:  Q99705 (UniProtKB)
Alt. Names/Synonyms: G protein-coupled receptor 24; G-protein coupled receptor 24; GPR24; MCH receptor 1; MCH-1R; MCH-R1; MCH1R; MCHR; MCHR-1; MCHR1; melanin concentrating hormone receptor 1; Melanin-concentrating hormone receptor 1; MGC32129; SLC-1; SLC1; Somatostatin receptor-like protein
Gene Symbols: MCHR1
Molecular weight: 45,963 Da
Basal Isoelectric point: 9.23  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB