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MCHR1
Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. Belongs to the G-protein coupled receptor 1 family. Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of human Ortholog: 22q13.2 |
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Cellular Component:
ciliary membrane; cilium; neuron projection; non-motile cilium; plasma membrane
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Molecular Function:
G protein-coupled receptor activity; hormone binding; melanin-concentrating hormone receptor activity; neuropeptide binding; neuropeptide receptor activity; peptide binding; protein C-terminus binding; signaling receptor binding
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Biological Process:
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; feeding behavior; G protein-coupled receptor signaling pathway; generation of precursor metabolites and energy; neuropeptide signaling pathway; positive regulation of calcium ion transport; positive regulation of cytosolic calcium ion concentration
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Reference #:
Q99705
(UniProtKB)
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Alt. Names/Synonyms: G protein-coupled receptor 24; G-protein coupled receptor 24; GPR24; MCH receptor 1; MCH-1R; MCH-R1; MCH1R; MCHR; MCHR-1; MCHR1; melanin concentrating hormone receptor 1; Melanin-concentrating hormone receptor 1; MGC32129; SLC-1; SLC1; Somatostatin receptor-like protein
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Gene Symbols: MCHR1
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Molecular weight:
45,963 Da
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Basal Isoelectric point:
9.23
Predict pI for various phosphorylation states
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