GCLM
Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily. In all tissues examined. Highest levels in skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Other Amino Acids Metabolism - glutathione |
Chromosomal Location of human Ortholog: 1p22.1 |
Cellular Component:
cytosol; glutamate-cysteine ligase complex
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Molecular Function:
enzyme regulator activity; glutamate-cysteine ligase activity; glutamate-cysteine ligase catalytic subunit binding; protein binding; protein-containing complex binding
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Biological Process:
apoptotic mitochondrial changes; blood vessel diameter maintenance; cellular response to fibroblast growth factor stimulus; cellular response to follicle-stimulating hormone stimulus; cellular response to glucose stimulus; cellular response to hepatocyte growth factor stimulus; cellular response to leukemia inhibitory factor; cellular response to thyroxine stimulus; cysteine metabolic process; glutamate metabolic process; glutathione biosynthetic process; hepatic stellate cell activation; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of neuron apoptotic process; positive regulation of glutamate-cysteine ligase activity; regulation of mitochondrial depolarization; response to activity; response to human chorionic gonadotropin; response to nitrosative stress; response to nutrient; response to oxidative stress; response to xenobiotic stimulus
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Disease: Myocardial Infarction, Susceptibility To
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Reference #:
P48507
(UniProtKB)
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Alt. Names/Synonyms: Gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; GCLM; GCS light chain; GLCLR; Glutamate--cysteine ligase modifier subunit; Glutamate--cysteine ligase regulatory subunit; glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD); glutamate-cysteine ligase modifier subunit; glutamate-cysteine ligase modifier subunit delta2 alternative splicing; glutamate-cysteine ligase regulatory protein; glutamate-cysteine ligase, modifier subunit; GSC light chain; GSH0
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Gene Symbols: GCLM
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Molecular weight:
30,727 Da
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Basal Isoelectric point:
5.7
Predict pI for various phosphorylation states
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