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NPY2R
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY Belongs to the G-protein coupled receptor 1 family. High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of human Ortholog: 4q32.1 |
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Cellular Component:
cilium; integral component of plasma membrane; non-motile cilium; plasma membrane
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Molecular Function:
calcium channel regulator activity; neuropeptide Y receptor activity; peptide YY receptor activity; protein binding; signaling receptor activity
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Biological Process:
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; aging; behavioral fear response; cardiac left ventricle morphogenesis; G protein-coupled receptor signaling pathway; locomotory behavior; negative regulation of cAMP-mediated signaling; negative regulation of excitatory postsynaptic potential; negative regulation of feeding behavior; negative regulation of secretion; negative regulation of synaptic transmission, glutamatergic; neuropeptide signaling pathway; nitric oxide mediated signal transduction; outflow tract morphogenesis; positive regulation of cell-substrate adhesion; positive regulation of circadian sleep/wake cycle, non-REM sleep; positive regulation of cytosolic calcium ion concentration; positive regulation of dopamine secretion; positive regulation of peptide secretion; positive regulation of smooth muscle contraction; regulation of sensory perception of pain; secretion
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Reference #:
P49146
(UniProtKB)
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Alt. Names/Synonyms: Neuropeptide Y receptor type 2; neuropeptide Y receptor Y2; NPY-Y2 receptor; NPY2-R; NPY2R; Y2 receptor
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Gene Symbols: NPY2R
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Molecular weight:
42,731 Da
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Basal Isoelectric point:
6.79
Predict pI for various phosphorylation states
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