NPY2R Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY Belongs to the G-protein coupled receptor 1 family. High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 4q32.1
Cellular Component:  cilium; integral component of plasma membrane; non-motile cilium; plasma membrane
Molecular Function:  calcium channel regulator activity; neuropeptide Y receptor activity; peptide YY receptor activity; protein binding; signaling receptor activity
Biological Process:  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; aging; behavioral fear response; cardiac left ventricle morphogenesis; G protein-coupled receptor signaling pathway; locomotory behavior; negative regulation of cAMP-mediated signaling; negative regulation of excitatory postsynaptic potential; negative regulation of feeding behavior; negative regulation of secretion; negative regulation of synaptic transmission, glutamatergic; neuropeptide signaling pathway; nitric oxide mediated signal transduction; outflow tract morphogenesis; positive regulation of cell-substrate adhesion; positive regulation of circadian sleep/wake cycle, non-REM sleep; positive regulation of cytosolic calcium ion concentration; positive regulation of dopamine secretion; positive regulation of peptide secretion; positive regulation of smooth muscle contraction; regulation of sensory perception of pain; secretion
Reference #:  P49146 (UniProtKB)
Alt. Names/Synonyms: Neuropeptide Y receptor type 2; neuropeptide Y receptor Y2; NPY-Y2 receptor; NPY2-R; NPY2R; Y2 receptor
Gene Symbols: NPY2R
Molecular weight: 42,731 Da
Basal Isoelectric point: 6.79  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene