ERCC6 Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II-blocking lesions. Belongs to the SNF2/RAD54 helicase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; EC 3.6.1.-; EC 3.6.4.-; Helicase; Transcription regulation
Chromosomal Location of Human Ortholog: 14|14 B
Cellular Component:  nucleolus; nucleoplasm; nucleus; transcription elongation factor complex
Molecular Function:  ATP binding; chromatin binding; DNA binding; DNA-dependent ATPase activity; protein C-terminus binding; protein N-terminus binding; protein tyrosine kinase activator activity; protein-containing complex binding; sequence-specific DNA binding
Biological Process:  activation of JNKK activity; activation of JUN kinase activity; base-excision repair; cellular response to DNA damage stimulus; DNA repair; intrinsic apoptotic signaling pathway in response to DNA damage; multicellular organism growth; photoreceptor cell maintenance; positive regulation of defense response to virus by host; positive regulation of DNA repair; positive regulation of DNA-templated transcription, elongation; positive regulation of gene expression; positive regulation of peptidyl-serine phosphorylation of STAT protein; pyrimidine dimer repair; regulation of DNA-templated transcription, elongation; response to gamma radiation; response to oxidative stress; response to superoxide; response to toxic substance; response to UV; response to UV-B; response to X-ray; transcription elongation from RNA polymerase I promoter; transcription-coupled nucleotide-excision repair
Reference #:  F8VPZ5 (UniProtKB)
Alt. Names/Synonyms: 4732403I04; ATP-dependent helicase ERCC6; C130058G22Rik; Cockayne syndrome protein CSB; CS group B correcting; CSB; DNA excision repair protein ERCC-6; Ercc6; Excision repair cross-complementing rodent repair deficiency, complementation group 6
Gene Symbols: Ercc6
Molecular weight: 165,958 Da
Basal Isoelectric point: 8.18  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  Reactome  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein