NHE3 Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 5p15.33
Cellular Component:  apical plasma membrane; brush border; brush border membrane; cell surface; extracellular exosome; integral component of membrane; plasma membrane
Molecular Function:  PDZ domain binding; protein binding; sodium:proton antiporter activity
Biological Process:  ion transport; proton transmembrane transport; sodium ion import across plasma membrane
Disease: Diarrhea 8, Secretory Sodium, Congenital
Reference #:  P48764 (UniProtKB)
Alt. Names/Synonyms: MGC126718; MGC126720; Na(+)/H(+) exchanger 3; NHE-3; NHE3; SL9A3; SLC9A3; Sodium/hydrogen exchanger 3; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3; solute carrier family 9 (sodium/hydrogen exchanger), member 3; Solute carrier family 9 member 3
Gene Symbols: SLC9A3
Molecular weight: 92,855 Da
Basal Isoelectric point: 7.05  Predict pI for various phosphorylation states
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NHE3

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB