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NHE3
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family |
| Chromosomal Location of Human Ortholog: 5p15.33 |
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Cellular Component:
apical plasma membrane; brush border; brush border membrane; cell surface; extracellular exosome; integral component of membrane; plasma membrane
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Molecular Function:
PDZ domain binding; protein binding; sodium:proton antiporter activity
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Biological Process:
ion transport; proton transmembrane transport; sodium ion import across plasma membrane
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Disease: Diarrhea 8, Secretory Sodium, Congenital
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Reference #:
P48764
(UniProtKB)
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Alt. Names/Synonyms: MGC126718; MGC126720; Na(+)/H(+) exchanger 3; NHE-3; NHE3; SL9A3; SLC9A3; Sodium/hydrogen exchanger 3; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3; solute carrier family 9 (sodium/hydrogen exchanger), member 3; Solute carrier family 9 member 3
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Gene Symbols: SLC9A3
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Molecular weight:
92,855 Da
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Basal Isoelectric point:
7.05
Predict pI for various phosphorylation states
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