NHE3 Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of human Ortholog: 5p15.33
Cellular Component:  apical plasma membrane; brush border; brush border membrane; cell surface; early endosome; early endosome membrane; extracellular exosome; plasma membrane; recycling endosome membrane
Molecular Function:  identical protein binding; PDZ domain binding; phosphatidylinositol binding; potassium:proton antiporter activity; protein binding; sodium:proton antiporter activity
Biological Process:  monoatomic ion transport; potassium ion transmembrane transport; proton transmembrane transport; regulation of intracellular pH; sodium ion import across plasma membrane
Disease: Diarrhea 8, Secretory Sodium, Congenital
Reference #:  P48764 (UniProtKB)
Alt. Names/Synonyms: DIAR8; MGC126718; MGC126720; Na(+)/H(+) exchanger 3; NHE-3; NHE3; SL9A3; SLC9A3; Sodium/hydrogen exchanger 3; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3; solute carrier family 9 (sodium/hydrogen exchanger), member 3; Solute carrier family 9 member 3; solute carrier family 9 member A3; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
Gene Symbols: SLC9A3
Molecular weight: 92,855 Da
Basal Isoelectric point: 7.05  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein