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NHE3
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family |
| Chromosomal Location of human Ortholog: 5p15.33 |
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Cellular Component:
apical plasma membrane; brush border; brush border membrane; cell surface; extracellular exosome; plasma membrane
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Molecular Function:
PDZ domain binding; potassium:proton antiporter activity; protein binding; sodium:proton antiporter activity
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Biological Process:
ion transport; potassium ion transmembrane transport; proton transmembrane transport; regulation of intracellular pH; sodium ion import across plasma membrane
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Disease: Diarrhea 8, Secretory Sodium, Congenital
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Reference #:
P48764
(UniProtKB)
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Alt. Names/Synonyms: DIAR8; MGC126718; MGC126720; Na(+)/H(+) exchanger 3; NHE-3; NHE3; SL9A3; SLC9A3; Sodium/hydrogen exchanger 3; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3; solute carrier family 9 (sodium/hydrogen exchanger), member 3; Solute carrier family 9 member 3; solute carrier family 9 member A3; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
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Gene Symbols: SLC9A3
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Molecular weight:
92,855 Da
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Basal Isoelectric point:
7.05
Predict pI for various phosphorylation states
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