CAPN2 Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. Belongs to the peptidase C2 family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protease
Chromosomal Location of Human Ortholog: 1|1 H5
Cellular Component:  cell projection; chromatin; cytoplasm; cytosol; dendrite; endoplasmic reticulum; external side of plasma membrane; focal adhesion; Golgi apparatus; lysosome; membrane; membrane raft; neuronal cell body; nucleus; perinuclear endoplasmic reticulum; plasma membrane; pseudopodium
Molecular Function:  calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; cysteine-type peptidase activity; cytoskeletal protein binding; enzyme binding; hydrolase activity; metal ion binding; peptidase activity; protein heterodimerization activity
Biological Process:  behavioral response to pain; blastocyst development; cellular response to amino acid stimulus; myoblast fusion; positive regulation of cardiac muscle cell apoptotic process; positive regulation of myoblast fusion; positive regulation of neuron death; positive regulation of phosphatidylcholine biosynthetic process; protein autoprocessing; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of cytoskeleton organization; regulation of interleukin-6 production
Reference #:  O08529 (UniProtKB)
Alt. Names/Synonyms: 80 kDa M-calpain subunit; AI326419; Calcium-activated neutral proteinase 2; CALP80; calpain 2; Calpain M-type; Calpain-2 catalytic subunit; Calpain-2 large subunit; CAN2; CANP 2; Capa-2; Capa2; Capn2; cysteine proteinase; M-calpain; m-calpain 80 kDa large subunit; m-calpain large subunit; m-calpin; Millimolar-calpain
Gene Symbols: Capn2
Molecular weight: 79,872 Da
Basal Isoelectric point: 4.86  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Apoptosis Regulation  |  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene