EPB41 Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of human Ortholog: 1p35.3
Cellular Component:  basolateral plasma membrane; cell cortex; cell junction; cortical cytoskeleton; cytoplasmic side of plasma membrane; cytoskeleton; cytosol; intercellular bridge; mitotic spindle; nuclear body; plasma membrane; protein-containing complex; spectrin-associated cytoskeleton
Molecular Function:  1-phosphatidylinositol binding; actin binding; calmodulin binding; phosphoprotein binding; protein binding; spectrin binding; structural constituent of cytoskeleton
Biological Process:  actin cytoskeleton organization; actomyosin structure organization; cell cycle; cell division; cortical actin cytoskeleton organization; positive regulation of protein binding; positive regulation of protein localization to cell cortex; protein-containing complex assembly; regulation of calcium ion transport; regulation of intestinal absorption
Disease: Elliptocytosis 1; Pyropoikilocytosis, Hereditary
Reference #:  P11171 (UniProtKB)
Alt. Names/Synonyms: 4.1R; 41; Band 4.1; E41P; EL1; elliptocytosis 1, RH-linked; EPB4.1; EPB41; erythrocyte membrane protein band 4.1; erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked); erythrocyte surface protein band 4.1; HE; P4.1; Protein 4.1
Gene Symbols: EPB41
Molecular weight: 97,017 Da
Basal Isoelectric point: 5.42  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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