KIF23 Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 9|9 B
Cellular Component:  centralspindlin complex; centrosome; cytoplasm; cytoskeleton; intercellular bridge; kinesin complex; microtubule; midbody; mitotic spindle; nucleoplasm; nucleus; spindle
Molecular Function:  ATP binding; ATPase activity; microtubule binding; microtubule motor activity; nucleotide binding
Biological Process:  actomyosin contractile ring assembly; cell cycle; cell division; microtubule-based movement; mitotic cytokinesis; mitotic spindle midzone assembly; plus-end-directed vesicle transport along microtubule; positive regulation of cytokinesis
Reference #:  E9Q5G3 (UniProtKB)
Alt. Names/Synonyms: 3110001D19Rik; C87313; CHO; CHO1; Kif23; Kinesin family member 23; kinesin-like 5 (mitotic kinesin-like protein 1); Kinesin-like protein KIF23; Knsl5; MKL; MKLP; MKLP-1; MKLP1
Gene Symbols: Kif23
Molecular weight: 108,776 Da
Basal Isoelectric point: 8.89  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene