|
KIF23
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor |
| Chromosomal Location of mouse Ortholog: 9|9 B |
|
Cellular Component:
centralspindlin complex; centrosome; cytoplasm; cytoskeleton; Flemming body; intercellular bridge; kinesin complex; microtubule; midbody; mitotic spindle; nucleoplasm; nucleus; spindle
|
|
Molecular Function:
ATP binding; ATP hydrolysis activity; microtubule binding; microtubule motor activity; nucleotide binding
|
|
Biological Process:
cell cycle; cell division; microtubule-based movement; mitotic cytokinesis; mitotic spindle midzone assembly; positive regulation of cytokinesis
|
|
Reference #:
E9Q5G3
(UniProtKB)
|
|
Alt. Names/Synonyms: 3110001D19Rik; C87313; CHO; CHO1; Kif23; Kinesin family member 23; kinesin-like 5 (mitotic kinesin-like protein 1); Kinesin-like protein KIF23; Knsl5; MKL; MKLP; MKLP-1; MKLP1
|
|
Gene Symbols: Kif23
|
|
Molecular weight:
108,776 Da
|
|
Basal Isoelectric point:
8.89
Predict pI for various phosphorylation states
|
