TUBB3
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord. Belongs to the tubulin family. Expression is primarily restricted to central and peripheral nervous system. Greatly increased expression in most cancerous tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
Chromosomal Location of rat Ortholog: 19q12 |
Cellular Component:
axon; cell periphery; cytoplasm; dendrite; filopodium; growth cone; intercellular bridge; lamellipodium; microtubule; microtubule cytoskeleton; mitotic spindle; neuronal cell body
|
Molecular Function:
GTP binding; GTPase activity; metal ion binding; netrin receptor binding; peptide binding; structural constituent of cytoskeleton
|
Biological Process:
axon guidance; dorsal root ganglion development; microtubule cytoskeleton organization; mitotic cell cycle; netrin-activated signaling pathway; neuron differentiation
|
Reference #:
Q4QRB4
(UniProtKB)
|
Alt. Names/Synonyms: Neuron-specific class III beta-tubulin; TBB3; Tubb3; Tubulin beta-3 chain; tubulin, beta 3
|
Gene Symbols: Tubb3
|
Molecular weight:
50,419 Da
|
Basal Isoelectric point:
4.82
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|