TTP a CCCH zinc finger protein that has anti-inflammatory and arthritis suppressor activity. Regulates inflammatory responses at the post-transcriptional level. TTP deficiency in mice causes a severe inflammatory syndrome that includes autoimmunity, myeloid hyperplasia, and erosive arthritis. Binds to and destabilizes mRNA molecules with AU-rich elements (AREs). Has a high affinity for UUAUUUAUU mRNA sequences. Destabilizes tumor necrosis factor-alpha (TNF??), interleukin 2 (IL2), granulocyte-macrophage colony-stimulating factor (GM-CSF), transcription factor E47, and cyclooxygenase 2 (COX2) mRNAs. TNF?? and GM-CSF mRNAs are stabilized in TTP-deficient mice, causing a severe inflammatory syndrome. Conversely, high levels of TTP reduce inflammatory responses. TTP is a very low abundance protein that is rapidly induced by insulin, glucocorticoids, lipopolysaccharide (LPS), fetal calf serum, zinc, herpes simplex virus 1, green tea, and cinnamon. Once induced, the TTP protein is relatively stable. Has been experimentaly shown to be able to bind zinc. TTP is extensively phosphorylated. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; RNA-binding
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component:  cytoplasm; cytoplasmic stress granule; cytosol; nucleus; P-body; ribonucleoprotein complex
Molecular Function:  14-3-3 protein binding; C-C chemokine binding; DNA binding; enzyme binding; heat shock protein binding; metal ion binding; mRNA 3'-UTR AU-rich region binding; mRNA binding; protein binding; protein kinase binding; RNA polymerase binding
Biological Process:  3'-UTR-mediated mRNA destabilization; 3'-UTR-mediated mRNA stabilization; cellular response to epidermal growth factor stimulus; cellular response to fibroblast growth factor stimulus; cellular response to glucocorticoid stimulus; cellular response to granulocyte macrophage colony-stimulating factor stimulus; cellular response to lipopolysaccharide; cellular response to tumor necrosis factor; MAPK cascade; miRNA mediated inhibition of translation; mRNA catabolic process; mRNA transport; negative regulation of erythrocyte differentiation; negative regulation of interleukin-2 biosynthetic process; negative regulation of polynucleotide adenylyltransferase activity; negative regulation of transcription by RNA polymerase II; negative regulation of viral transcription; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; nuclear-transcribed mRNA catabolic process, deadenylation-independent decay; nuclear-transcribed mRNA poly(A) tail shortening; p38MAPK cascade; positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA; positive regulation of fat cell differentiation; positive regulation of gene silencing by miRNA; positive regulation of intracellular mRNA localization; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; regulation of keratinocyte apoptotic process; regulation of keratinocyte differentiation; regulation of keratinocyte proliferation; regulation of mRNA stability; regulation of tumor necrosis factor production; response to starvation; response to wounding
Reference #:  P26651 (UniProtKB)
Alt. Names/Synonyms: G0/G1 switch regulatory protein 24; G0S24; GOS24; Growth factor-inducible nuclear protein NUP475; mRNA decay activator protein ZFP36; NUP475; Protein TIS11A; RNF162A; TIS11; TIS11A; tristetraprolin; Tristetraproline; TTP; Zfp-36; ZFP36; Zinc finger protein 36 homolog; zinc finger protein 36, C3H type, homolog (mouse); zinc finger protein, C3H type, 36 homolog
Gene Symbols: ZFP36
Molecular weight: 34,003 Da
Basal Isoelectric point: 8.86  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TTP

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene