CD40 Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion. B-cells and in primary carcinomas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 20q13.12
Cellular Component:  CD40 receptor complex; cytoplasm; external side of plasma membrane; integral component of plasma membrane; intracellular membrane-bounded organelle; neuronal cell body; plasma membrane; varicosity
Molecular Function:  antigen binding; enzyme binding; protein binding; protein domain specific binding; signaling receptor activity; ubiquitin protein ligase binding
Biological Process:  B cell proliferation; cellular calcium ion homeostasis; cellular response to erythropoietin; cellular response to interleukin-1; cellular response to lipopolysaccharide; cellular response to mechanical stimulus; defense response to protozoan; defense response to virus; immune response-regulating cell surface receptor signaling pathway; inflammatory response; platelet activation; positive regulation of angiogenesis; positive regulation of B cell proliferation; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell apoptotic process; positive regulation of GTPase activity; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-12 production; positive regulation of isotype switching to IgG isotypes; positive regulation of MAP kinase activity; positive regulation of NF-kappaB transcription factor activity; positive regulation of protein kinase C signaling; positive regulation of protein phosphorylation; positive regulation of transcription by RNA polymerase II; positive regulation of tyrosine phosphorylation of STAT protein; protein kinase B signaling; protein-containing complex assembly; regulation of immune response; regulation of immunoglobulin secretion; response to cobalamin; response to interferon-gamma; response to peptide; tumor necrosis factor-mediated signaling pathway
Disease: Immunodeficiency With Hyper-igm, Type 3
Reference #:  P25942 (UniProtKB)
Alt. Names/Synonyms: B cell surface antigen CD40; B cell-associated molecule; B-cell surface antigen CD40; Bp50; CD40; CD40 antigen (TNF receptor superfamily member 5); CD40 molecule, TNF receptor superfamily member 5; CD40 type II isoform; CD40L receptor; CDw40; MGC9013; nerve growth factor receptor-related B-lymphocyte activation molecule; p50; TNFRSF5; TNR5; Tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5
Gene Symbols: CD40
Molecular weight: 30,619 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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