HER3 Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation. Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. Epithelial tissues and brain. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; EGFR family; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of mouse Ortholog: 10 D3|10 77.1 cM
Cellular Component:  apical plasma membrane; basal plasma membrane; basolateral plasma membrane; ERBB3:ERBB2 complex; extracellular space; lateral plasma membrane; membrane; plasma membrane; postsynaptic membrane; receptor complex
Molecular Function:  ATP binding; ErbB-3 class receptor binding; growth factor binding; identical protein binding; kinase activity; neuregulin binding; neuregulin receptor activity; nucleotide binding; protein binding; protein heterodimerization activity; protein kinase activity; protein tyrosine kinase activator activity; protein tyrosine kinase activity; signaling receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane signaling receptor activity; ubiquitin protein ligase binding
Biological Process:  cranial nerve development; endocardial cushion development; epidermal growth factor receptor signaling pathway; ERBB2-ERBB3 signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; motor neuron apoptotic process; multicellular organism development; negative regulation of apoptotic process; negative regulation of cell adhesion; negative regulation of motor neuron apoptotic process; negative regulation of neuron apoptotic process; negative regulation of secretion; negative regulation of signal transduction; neurogenesis; neuron apoptotic process; peripheral nervous system development; phosphatidylinositol 3-kinase signaling; phosphorylation; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of cardiac muscle tissue development; positive regulation of cell population proliferation; positive regulation of gene expression; positive regulation of glucose import; positive regulation of kinase activity; positive regulation of protein tyrosine kinase activity; protein phosphorylation; regulation of cell population proliferation; Schwann cell differentiation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q61526 (UniProtKB)
Alt. Names/Synonyms: avian erythroblastosis oncogene B 3 receptor; c-erbB-3; C76256; erb-b2 receptor tyrosine kinase 3; Erbb; Erbb-; Erbb-3; Erbb3; Erbb3r; Glial growth factor receptor; HER; Her3; MGC117742; Proto-oncogene-like protein c-ErbB-3; Receptor tyrosine-protein kinase erbB-3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Gene Symbols: Erbb3
Molecular weight: 147,613 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein