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Fe65
a transcription coregulator adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on Y142 (H2AXpY142) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as TIP60, probably explains its trancription activation activity. Functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Highly expressed in brain; strongly reduced in elderly subjects with Alzheimer disease. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Apoptosis; Transcription regulation |
| Chromosomal Location of human Ortholog: 11p15.4 |
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Cellular Component:
cytoplasm; endoplasmic reticulum; growth cone; lamellipodium; nuclear speck; nucleoplasm; nucleus; plasma membrane; synapse
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Molecular Function:
amyloid-beta binding; chromatin binding; histone binding; low-density lipoprotein particle receptor binding; proline-rich region binding; protein binding; transcription coactivator activity; transcription factor binding; ubiquitin protein ligase binding
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Biological Process:
apoptotic process; axonogenesis; chromatin organization; DNA damage response; negative regulation of cell cycle G1/S phase transition; negative regulation of transcription by RNA polymerase II; positive regulation of apoptotic process; positive regulation of DNA-templated transcription; positive regulation of protein secretion; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; signal transduction; smooth muscle contraction
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Reference #:
O00213
(UniProtKB)
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Alt. Names/Synonyms: adaptor protein FE65a2; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); Amyloid beta A4 precursor protein-binding family B member 1; amyloid beta A4 precursor protein-binding, family B, member 1; Amyloid beta precursor protein binding family B member 1; Amyloid-beta A4 precursor protein-binding family B member 1; APBB1; FE65; MGC:9072; Protein Fe65; RIR; stat-like protein
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Gene Symbols: APBB1
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Molecular weight:
77,244 Da
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Basal Isoelectric point:
4.98
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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