Fe65 a transcription coregulator adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on Y142 (H2AXpY142) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as TIP60, probably explains its trancription activation activity. Functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Highly expressed in brain; strongly reduced in elderly subjects with Alzheimer disease. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Apoptosis; Transcription regulation
Chromosomal Location of Human Ortholog: 7 E3|7 55.9 cM
Cellular Component:  cell projection; cytoplasm; dendritic spine; glutamatergic synapse; growth cone; growth cone filopodium; growth cone lamellipodium; lamellipodium; main axon; membrane; neuromuscular junction; neuronal cell body; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic membrane; presynapse; presynaptic membrane; protein-containing complex; Schaffer collateral - CA1 synapse; synapse
Molecular Function:  amyloid-beta binding; chromatin binding; histone acetyltransferase binding; histone binding; proline-rich region binding; protein binding; protein-containing complex binding; tau protein binding; transcription factor binding; ubiquitin protein ligase binding
Biological Process:  actin filament-based movement; apoptotic process; axon guidance; cell cycle arrest; cellular response to DNA damage stimulus; chromatin organization; double-strand break repair; extracellular matrix organization; histone H4 acetylation; negative regulation of cell growth; negative regulation of neuron differentiation; negative regulation of thymidylate synthase biosynthetic process; negative regulation of transcription by RNA polymerase II; neuron migration; positive regulation of apoptotic process; positive regulation of DNA repair; positive regulation of neuron projection development; positive regulation of protein secretion; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein stabilization; regulation of transcription, DNA-templated; synapse organization; visual learning
Reference #:  Q9QXJ1 (UniProtKB)
Alt. Names/Synonyms: amyloid beta (A4) precursor protein-binding, family B, member 1; Amyloid beta A4 precursor protein-binding family B member 1; Amyloid-beta A4 precursor protein-binding family B member 1; Apbb1; Fe65; Protein Fe65; Rir
Gene Symbols: Apbb1
Molecular weight: 77,384 Da
Basal Isoelectric point: 4.93  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene