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Fe65
a transcription coregulator adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on Y142 (H2AXpY142) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as TIP60, probably explains its trancription activation activity. Functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Highly expressed in brain; strongly reduced in elderly subjects with Alzheimer disease. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Apoptosis; Transcription regulation |
| Chromosomal Location of mouse Ortholog: 7 E3|7 55.9 cM |
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Cellular Component:
cell projection; cytoplasm; dendritic spine; endoplasmic reticulum; glutamatergic synapse; growth cone; growth cone filopodium; growth cone lamellipodium; lamellipodium; main axon; membrane; neuromuscular junction; neuronal cell body; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic membrane; presynapse; presynaptic membrane; protein-containing complex; Schaffer collateral - CA1 synapse; synapse
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Molecular Function:
amyloid-beta binding; chromatin binding; DNA-binding transcription factor binding; histone binding; proline-rich region binding; protein binding; protein-containing complex binding; tau protein binding; transcription factor binding; ubiquitin protein ligase binding
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Biological Process:
apoptotic process; axon guidance; chromatin organization; DNA damage response; DNA repair-dependent chromatin remodeling; double-strand break repair; extracellular matrix organization; negative regulation of cell cycle G1/S phase transition; negative regulation of neuron differentiation; negative regulation of transcription by RNA polymerase II; neuron differentiation; neuron migration; positive regulation of apoptotic process; positive regulation of DNA repair; positive regulation of DNA-templated transcription; positive regulation of neuron projection development; positive regulation of protein secretion; positive regulation of transcription by RNA polymerase II; protein stabilization; regulation of DNA-templated transcription; smooth muscle contraction; synapse organization
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Reference #:
Q9QXJ1
(UniProtKB)
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Alt. Names/Synonyms: amyloid beta (A4) precursor protein-binding, family B, member 1; Amyloid beta A4 precursor protein-binding family B member 1; Amyloid beta precursor protein binding family B member 1; Amyloid-beta A4 precursor protein-binding family B member 1; Apbb1; Fe65; Protein Fe65; Rir
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Gene Symbols: Apbb1
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Molecular weight:
77,384 Da
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Basal Isoelectric point:
4.93
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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