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DAT
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily. Highly expressed in substantia nigra. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family |
| Chromosomal Location of mouse Ortholog: 13 C1|13 40.1 cM |
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Cellular Component:
axon; axon terminus; cell projection; cell surface; dopaminergic synapse; flotillin complex; membrane; membrane raft; neuron projection; neuronal cell body; neuronal cell body membrane; plasma membrane; postsynaptic membrane; presynaptic membrane
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Molecular Function:
amine binding; dopamine binding; dopamine:sodium symporter activity; heterocyclic compound binding; metal ion binding; monoamine transmembrane transporter activity; neurotransmitter transmembrane transporter activity; norepinephrine:sodium symporter activity; protease binding; protein binding; protein phosphatase 2A binding; protein-containing complex binding; signaling receptor binding; symporter activity
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Biological Process:
adenohypophysis development; dopamine biosynthetic process; dopamine catabolic process; dopamine transport; dopamine uptake; dopamine uptake involved in synaptic transmission; hyaloid vascular plexus regression; lactation; locomotory behavior; monoamine transport; neurotransmitter transport; neurotransmitter uptake; norepinephrine transport; positive regulation of multicellular organism growth; prepulse inhibition; regulation of dopamine metabolic process; response to cAMP; response to cocaine; response to ethanol; sensory perception of smell; sodium ion transmembrane transport
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Reference #:
Q61327
(UniProtKB)
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Alt. Names/Synonyms: DA transporter; DAT; Dat1; dopamine transporter 1; SC6A3; Slc6a3; Sodium-dependent dopamine transporter; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; Solute carrier family 6 member 3
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Gene Symbols: Slc6a3
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Molecular weight:
68,805 Da
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Basal Isoelectric point:
6.82
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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