DAT Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily. Highly expressed in substantia nigra. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of rat Ortholog: 1p11
Cellular Component:  axon; cell surface; dopaminergic synapse; flotillin complex; integral component of postsynaptic membrane; integral component of presynaptic membrane; membrane raft; neuron projection; neuronal cell body; plasma membrane
Molecular Function:  dopamine binding; dopamine:sodium symporter activity; drug binding; metal ion binding; monoamine transmembrane transporter activity; neurotransmitter:sodium symporter activity; protease binding; protein N-terminus binding; protein phosphatase 2A binding; protein-containing complex binding; signaling receptor binding
Biological Process:  adenohypophysis development; aging; dopamine biosynthetic process; dopamine catabolic process; dopamine transport; dopamine uptake; lactation; locomotory behavior; monoamine transport; neurotransmitter uptake; positive regulation of multicellular organism growth; prepulse inhibition; regulation of dopamine metabolic process; response to cAMP; response to cocaine; response to drug; response to ethanol; response to iron ion; response to nicotine; response to organic cyclic compound; sensory perception of smell; transmembrane transport
Reference #:  P23977 (UniProtKB)
Alt. Names/Synonyms: DA transporter; DAT; Dat1; SC6A3; Slc6a3; Sodium-dependent dopamine transporter; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; Solute carrier family 6 member 3; solute carrier family 6, member 3
Gene Symbols: Slc6a3
Molecular weight: 68,746 Da
Basal Isoelectric point: 6.63  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene