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DAT
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily. Highly expressed in substantia nigra. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family |
| Chromosomal Location of rat Ortholog: 1p11 |
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Cellular Component:
axon; cell surface; dopaminergic synapse; flotillin complex; integral component of postsynaptic membrane; integral component of presynaptic membrane; membrane raft; neuron projection; neuronal cell body; plasma membrane
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Molecular Function:
dopamine binding; dopamine:sodium symporter activity; drug binding; metal ion binding; monoamine transmembrane transporter activity; neurotransmitter:sodium symporter activity; protease binding; protein N-terminus binding; protein phosphatase 2A binding; protein-containing complex binding; signaling receptor binding
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Biological Process:
adenohypophysis development; aging; dopamine biosynthetic process; dopamine catabolic process; dopamine transport; dopamine uptake; lactation; locomotory behavior; monoamine transport; neurotransmitter uptake; positive regulation of multicellular organism growth; prepulse inhibition; regulation of dopamine metabolic process; response to cAMP; response to cocaine; response to drug; response to ethanol; response to iron ion; response to nicotine; response to organic cyclic compound; sensory perception of smell; transmembrane transport
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Reference #:
P23977
(UniProtKB)
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Alt. Names/Synonyms: DA transporter; DAT; Dat1; SC6A3; Slc6a3; Sodium-dependent dopamine transporter; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; Solute carrier family 6 member 3; solute carrier family 6, member 3
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Gene Symbols: Slc6a3
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Molecular weight:
68,746 Da
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Basal Isoelectric point:
6.63
Predict pI for various phosphorylation states
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