TEBP Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway. Belongs to the p23/wos2 family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Chaperone; EC 5.3.99.3; Isomerase; Nuclear receptor co-regulator; Transferase
Chromosomal Location of Human Ortholog: 12q13.3|12
Cellular Component:  chaperone complex; chromosome, telomeric region; cytosol; nucleoplasm; protein-containing complex; telomerase holoenzyme complex
Molecular Function:  DNA polymerase binding; Hsp90 protein binding; prostaglandin-E synthase activity; protein binding; telomerase activity; unfolded protein binding
Biological Process:  chaperone cofactor-dependent protein refolding; chaperone-mediated protein complex assembly; cyclooxygenase pathway; positive regulation of phosphorylation; positive regulation of telomerase activity; prostaglandin biosynthetic process; protein stabilization; regulation of cellular response to heat; signal transduction; telomerase holoenzyme complex assembly; telomere maintenance; telomere maintenance via telomerase; xenobiotic metabolic process
Reference #:  Q15185 (UniProtKB)
Alt. Names/Synonyms: cPGES; cytosolic prostaglandin E synthase; Cytosolic prostaglandin E2 synthase; Hsp90 co-chaperone; P23; Progesterone receptor complex p23; Prostaglandin E synthase 3; prostaglandin E synthase 3 (cytosolic); PTGES3; TEBP; Telomerase-binding protein p23; unactive progesterone receptor, 23 kD
Gene Symbols: PTGES3
Molecular weight: 18,697 Da
Basal Isoelectric point: 4.35  Predict pI for various phosphorylation states
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TEBP

Protein Structure Not Found.


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