TEBP
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway. Belongs to the p23/wos2 family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Chaperone; EC 5.3.99.3; Isomerase; Nuclear receptor co-regulator; Transferase |
Chromosomal Location of human Ortholog: 12q13.3|12 |
Cellular Component:
chromosome, telomeric region; cytosol; nucleoplasm; nucleus; protein folding chaperone complex; protein-containing complex; telomerase holoenzyme complex
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Molecular Function:
DNA polymerase binding; Hsp90 protein binding; prostaglandin-E synthase activity; protein binding; protein-folding chaperone binding; telomerase activity; unfolded protein binding
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Biological Process:
chaperone cofactor-dependent protein refolding; chaperone-mediated protein complex assembly; cyclooxygenase pathway; fibroblast proliferation; glucocorticoid receptor signaling pathway; glycogen biosynthetic process; lung saccule development; positive regulation of phosphorylation; positive regulation of telomerase activity; prostaglandin biosynthetic process; protein folding; protein stabilization; signal transduction; skin development; telomerase holoenzyme complex assembly; telomere maintenance; telomere maintenance via telomerase
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Reference #:
Q15185
(UniProtKB)
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Alt. Names/Synonyms: cPGES; cytosolic prostaglandin E synthase; Cytosolic prostaglandin E2 synthase; Hsp90 co-chaperone; P23; Progesterone receptor complex p23; Prostaglandin E synthase 3; prostaglandin E synthase 3 (cytosolic); PTGES3; TEBP; Telomerase-binding protein p23; unactive progesterone receptor, 23 kD
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Gene Symbols: PTGES3
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Molecular weight:
18,697 Da
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Basal Isoelectric point:
4.35
Predict pI for various phosphorylation states
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