MDS024 Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs. Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - histidine; Amino Acid Metabolism - tyrosine; EC 2.1.1.-; Lipid Metabolism - androgen and estrogen; Methyltransferase; Other Amino Acids Metabolism - selenoamino acid; RNA-binding
Chromosomal Location of Human Ortholog: 1p11
Cellular Component:  cytoplasm
Molecular Function:  methyltransferase activity; nucleic acid binding; tRNA (guanine-N2-)-methyltransferase activity; tRNA binding
Biological Process:  methylation; tRNA methylation
Reference #:  Q7TNK6 (UniProtKB)
Alt. Names/Synonyms: Mds024; putative RNA methylase MDS024; TRM11; Trmt11; tRNA (guanine(10)-N2)-methyltransferase homolog; tRNA guanosine-2'-O-methyltransferase TRM11 homolog; tRNA methyltransferase 11 homolog (S. cerevisiae)
Gene Symbols: Trmt11
Molecular weight: 53,103 Da
Basal Isoelectric point: 8.02  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene