axin 2
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. Expressed in brain and lymphoblast. Note: This description may include information from UniProtKB.
|
Protein type: Adaptor/scaffold |
Chromosomal Location of human Ortholog: 17q24.1 |
Cellular Component:
beta-catenin destruction complex; centrosome; cytoplasm; cytosol; nucleus; plasma membrane
|
Molecular Function:
beta-catenin binding; enzyme binding; I-SMAD binding; molecular adaptor activity; protein binding; protein kinase binding; ubiquitin protein ligase binding
|
Biological Process:
aortic valve morphogenesis; bone mineralization; cell development; cellular response to dexamethasone stimulus; chondrocyte differentiation involved in endochondral bone morphogenesis; intramembranous ossification; maintenance of DNA repeat elements; mitral valve morphogenesis; mRNA stabilization; negative regulation of canonical Wnt signaling pathway; negative regulation of osteoblast differentiation; negative regulation of osteoblast proliferation; negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification; odontogenesis; osteoblast differentiation; osteoblast proliferation; positive regulation of epithelial to mesenchymal transition; positive regulation of fat cell differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; proteasome-mediated ubiquitin-dependent protein catabolic process; protein localization; regulation of centromeric sister chromatid cohesion; regulation of chondrocyte development; regulation of extracellular matrix organization; regulation of mismatch repair; secondary heart field specification; somitogenesis; stem cell proliferation; Wnt signaling pathway
|
Disease: Colorectal Cancer; Oligodontia-colorectal Cancer Syndrome
|
Reference #:
Q9Y2T1
(UniProtKB)
|
Alt. Names/Synonyms: Axil; axin 2; Axin-2; Axin-like protein; AXIN2; Axis inhibition protein 2; AXN2; Conductin; DKFZp781B0869; MGC10366; MGC126582; ODCRCS
|
Gene Symbols: AXIN2
|
Molecular weight:
93,568 Da
|
Basal Isoelectric point:
7.82
Predict pI for various phosphorylation states
|
CST Pathways:
ESC Pluripotency and Differentiation
|
Wnt/ß-Catenin Signaling
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|