axin 2 Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. Expressed in brain and lymphoblast. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of human Ortholog: 17q24.1
Cellular Component:  beta-catenin destruction complex; centrosome; cytoplasm; cytosol; nucleus; plasma membrane
Molecular Function:  beta-catenin binding; enzyme binding; I-SMAD binding; molecular adaptor activity; protein binding; protein kinase binding; ubiquitin protein ligase binding
Biological Process:  bone mineralization; cell death; cell development; cellular response to dexamethasone stimulus; chondrocyte differentiation involved in endochondral bone morphogenesis; intramembranous ossification; maintenance of DNA repeat elements; mRNA stabilization; negative regulation of canonical Wnt signaling pathway; negative regulation of cell population proliferation; negative regulation of osteoblast differentiation; negative regulation of osteoblast proliferation; negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification; odontogenesis; osteoblast differentiation; osteoblast proliferation; positive regulation of cell death; positive regulation of epithelial to mesenchymal transition; positive regulation of fat cell differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; proteasome-mediated ubiquitin-dependent protein catabolic process; protein localization; regulation of centromeric sister chromatid cohesion; regulation of chondrocyte development; regulation of mismatch repair; secondary heart field specification; somitogenesis; stem cell proliferation; Wnt signaling pathway
Disease: Colorectal Cancer; Oligodontia-colorectal Cancer Syndrome
Reference #:  Q9Y2T1 (UniProtKB)
Alt. Names/Synonyms: Axil; axin 2; Axin-2; Axin-like protein; AXIN2; Axis inhibition protein 2; AXN2; Conductin; DKFZp781B0869; MGC10366; MGC126582; ODCRCS
Gene Symbols: AXIN2
Molecular weight: 93,568 Da
Basal Isoelectric point: 7.82  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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axin 2

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene