VDAC1 Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. Belongs to the eukaryotic mitochondrial porin family. Heart, liver and skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: Channel, misc.; Membrane protein, integral; Mitochondrial
Chromosomal Location of Human Ortholog: 11 B1.3|11 31.86 cM
Cellular Component:  integral component of membrane; membrane; mitochondrial inner membrane; mitochondrial nucleoid; mitochondrial outer membrane; mitochondrial permeability transition pore complex; mitochondrion; plasma membrane; pore complex; protein-containing complex; synaptic vesicle
Molecular Function:  anion channel activity; identical protein binding; ion channel binding; nucleotide binding; porin activity; protein binding; protein kinase binding; protein-containing complex binding; voltage-gated anion channel activity
Biological Process:  anion transport; apoptotic process; behavioral fear response; chemical synaptic transmission; ion transport; learning; mitochondrial calcium ion transmembrane transport; negative regulation of reactive oxygen species metabolic process; neuron-neuron synaptic transmission; regulation of autophagy of mitochondrion; transmembrane transport
Reference #:  Q60932 (UniProtKB)
Alt. Names/Synonyms: AL033343; mVDAC1; mVDAC5; OTTMUSP00000005805; Outer mitochondrial membrane protein porin 1; Plasmalemmal porin; Vda; VDAC-1; VDAC-5; Vdac1; Vdac5; voltage-dependent anion channel 1; Voltage-dependent anion-selective channel protein 1; Voltage-dependent anion-selective channel protein 5
Gene Symbols: Vdac1
Molecular weight: 32,351 Da
Basal Isoelectric point: 8.55  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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VDAC1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene